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Human organism is a wonderful phenomenon. After the long and painful process of evolution our bodies are able of resisting considerable difference of temperatures, heal big wounds and knit broken bones. They are able of fighting back numerous infections, regenerating different injuries and restoring after hard nervous stress and strain. If we fail to avoid health troubles pain is the first price you have to pay.

Every single burn, bruise and scratch in our life is accompanied with pain. This awful throbbing sensation is the most hated feeling in the world, with all that we would not be able to survive without pain. Believe it or not but it is pain that makes us smart and more attentive to the needs of our body. It is the best companion of our health that is always there for you - sleepless and alert. You will not be able to forget about your health problem and hurt yourself even if you fall asleep. You will have no opportunity of ignoring your bad tooth until things turn totally wrong because pain won’t let you to! Absence of physical pain would have made us too thoughtless to pay the slightest attention to our health and well-being. Do you still hate pain, the best and the most reliable friend of yours?

But sometimes pain becomes completely unbearable and persons think it more desirable to die than to tolerate an awful nightmare like that. No wonder the mankind kept looking for drugs able of soothing pain. Today we have the power of chemistry and present-day pharmacology in addition to natural stuffs to create safe and highly effective means of resisting pain.

Analgesic medicines today are various and large in number. Some of them are derivations of natural ingredients, others are purely chemical compositions; there are also various combinations of the two. Tramadol is one of them. It is a centrally-acting analgesic used in resisting moderate to moderately severe pain. This drugs is rather new - it was developed German pharmaceutical company Grünenthal GmbH in the end of the 1970s. It was a successful synthetic analog of Codeine, the phenanthrene alkaloid and opioid. Just like Codeine, Tramadol turned out to be a full-fledged prodrug, too. Unlike Codeine, converted in our bodies to Morphine, Tramadol is metabolized into M-1. Both substances act upon the human opiate receptors or μ1 and μ2 receptors. Tramadol is also known for releasing the hormone of happiness in human brain and inhibiting the effect of norepinephrine.

Tramadol can provoke euphoria and respiratory depression, because it is a very addictive opioid having serotonergic and noradrenergic effects and influencing the μ-opioid receptors only. This unique distinctive feature of Tramadol and its major metabolites makes this med stand alone among other compounds of the opioid drug class - even Morphine does not have this extent of receptor subtype selectivity!

As we have told you before Tramadol, just like codeine and other opioids, are normally applied to manage moderate to moderately severe painful states as well as the most types of neuralgia. When medical men for the first time saw Tramadol influence on the noradrenergic and serotonergic systems of humans they believed the drug could be effective for overcoming the symptoms of depression, anxiety and phobias. However the addictiveness of Tramadol kept it from becoming a usual tranquilizer. Today Tramadol is sometimes used these purposes but only when other therapies failed. In this case rigid Tramadol dosage control and regular psychiatrist consultations are necessary!

Tramadol ways are not that easy. Being highly effective, the medicine can cause side effects and from strong addiction, that is why there are always patients who are ready to misuse. The German company Grünenthal GmbH has been repeatedly charged of producing Tramadol, which is very addictive and can have severe side effects, while the company is not informative enough and states that the drug showed little abuse liability in preliminary tests. Later in May 2009, the United States Food and Drug Administration issued a warning letter to the company of Johnson & Johnson, because they promoted Tramadol overstating the efficiency of the drug, and minimizing the possible serious risks. The 2010 Physicians Desk Reference inderlines different manufacturer warnings, which were not present in prior years. They contained strict warnings about:

- the addictive potential of Tramadol,
- the possibility of difficulty breathing,
- a new extended list of side effects including more dangerous cases,
- a fact that Tramadol should not to be used instead of opiate medications for addicts,
- a warning that Tramadol should not to be used to withdraw addict patients from opiate drugs,
- a warning that Tramadol should not to be used to manage long-term opiate addiction.

Tramadol is available as:

- solutions for both intravenous and intramuscular injections. The injection solutions are used in patient-controlled analgesia cases either as the sole agent or with another opioid agent such as Morphine;
- capsules which are believed to protect your stomach better;
- tablets (regular, extended release, chewable etc);
- suppositories for rectal administration;
- powders for compounding;
- liquids both with and without alcohol for oral and sub-lingual administration.

As a rule you can get Tramadol online as the tramadol hydrochloride for oral administration.

The usual dosage of Tramadol is 50 mg generic tablets made by several pharmaceutical companies. Effective pain-killing conjunctions with APAP such as Paracetamol and Acetaminophen are also widely available as Ultracet drug. In this case the tablet contains smaller dose of Tramadol (37.5 mg) and larger dose of APAP (325 mg).

Tramadol is a medicine with special unpleasant taste which is mildly bitter. All the same, it is less bitter than other opioids such as Morphine and Codeine. The maximum safe dosage of Tramadol for oral administration is 400 mg a day and 600 mg of Tramadol for parenteral administration.

To be on the safe sade you should never reach the top dosage of Tramadol! For instance, Ultracet tablets with 37.5 mg of tramadol and 325 mg of APAP in it is capped at 8 tablets a day, that is 300 mg of Tramadol. Ultram ER tablets containing Tramadol are available in 100, 200, and 300 mg/day doses, too.

It is absolutely dangerous to take Tramadol if:

- you are over 75 years old or under 18 years old;
- you have severely reduced renal (kidney) or hepatic (liver) functions;
- you take other opioids such as oxycodone, methadone, fentanyl, morphine.

Please, go to your practitioner before purchasing Tramadol no prescription required - he or she will tell you about the safest way of using Tramadol or will give you the reasons why you should not start this drug at all.

It is wrong to say that MDs and investigators know everything about Tramadol. This unique med is still being clinically tested. So, Tramadol proves to be effective and safe in managing diabetic neuropathy, post-herpetic neuralgia, fibromyalgia, restless leg syndrome, Anti-Depressant withdrawal aid (especially for Venlafaxine or Effexor), migraine headache, obsessive-compulsive disorder and premature ejaculation.

You will be surprised to find out that Tramadol is one of the most reliable and useful pills available to veterinarians for treating animals in pain. For instance, Tramadol may be used to treat post-operative, injury-related, and chronic pain in dogs, cats and other mammals. It is less harmful than some non-steroidal anti-inflammatory substances that may be fatal for animals. Tramadol dosage for animals for effective analgesia is 1-4 mg/kg. Overdosing can be fatal!

Pregnancy and breastfeeding Tramadol warning: please, note that Tramadol is extremely dangerous for the unborn baby! According to FDA classification it is a FDA pregnancy category C medicine that must not be taken by pregnant women unless the potential benefits of Tramadol outweigh the serious risks!

If the future mother uses the medicine during pregnancy, Tramadol causes serious and even deadly side effects in newborn babies including neonatal withdrawal. Tramadol is known to pass into breast milk that is not you should not breastfeed your nursing baby if you follow the course of Tramadol therapy!

The common adverse reactions of Tramadol include:

- nausea and vomiting, constipation, diarrhea, indigestion;
- sweating;
- drowsiness (less than with natural opioids);
- dizziness, fatigue;
- headache;
- dry mouth;
- seizures (very seldom in less than 1% of patients).

Please, do not fail to remember that almost 71% of all Tramadol patients experience some of the side effects listed above!

Tramadol withdrawal signs are also rather numerous. They are usual for patients who followed the course of Tramadol therapy for a long time taking high dosage of the medicine. People who took Tramadol as general pain relief can experience uncontrollable nervous tremors and muscle contracture if they dropped the med too abruptly. Anxiety and other similar sensations are also possible when you stopped Tramadol. Some patients develop respiratory depression common for opioid withdrawal. Some practitioners speak about negative effects of opioids on cognitive functioning and personality.

As you can see, Tramadol is a perfect way out if you are in pain, but it can become dangerous if you take in too long and in large amounts. If you keep asking yourself where can i order Tramadol, please, make an appointment with your medical man to find out the safest way of taking and stopping Tramadol before swallowing the first tablet. Think twice! Maybe you can survive without any opioids at all?